Habit-forming actions of nomifensine in nucleus accumbens

Psychopharmacology (Berl). 1995 Nov;122(2):194-7. doi: 10.1007/BF02246095.


Rats learned to lever-press when reinforced with response-contingent microinfusions of the dopamine uptake inhibitor nomifensine (1.7 nmol per injection) into the ventro-medial (shell) region of nucleus accumbens septi (NAS). The drug was not effective when similar injections were given either in random relation to lever-pressing, into the more dorso-lateral (core) region of NAS, or into the frontal cortex. Cocaine was also effective in NAS, but considerably less so. These data suggest that response-contingent dopamine uptake blockade within the NAS is sufficient to establish and maintain instrumental response habits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Conditioning, Operant / drug effects*
  • Dopamine Uptake Inhibitors / administration & dosage
  • Dopamine Uptake Inhibitors / pharmacology*
  • Male
  • Microinjections
  • Nomifensine / administration & dosage
  • Nomifensine / pharmacology*
  • Nucleus Accumbens / anatomy & histology
  • Nucleus Accumbens / drug effects
  • Nucleus Accumbens / physiology*
  • Prefrontal Cortex
  • Rats
  • Reward
  • Self Administration


  • Dopamine Uptake Inhibitors
  • Nomifensine