The occurrence of 2-hydroxyisovaleric acid in patients with lactic acidosis and ketoacidosis

Clin Chim Acta. 1977 Aug 1;78(3):489-93. doi: 10.1016/0009-8981(77)90082-1.

Abstract

Examination of urine samples by capillary column gas chromatography and mass spectrometry showed the presence of 2-hydroxyisovaleric acid together with trace amounts of the three branched-chain 2-keto acids in five patients with lactic and ketoacidosis. None of these compounds was detected in urine from healthy controls.

MeSH terms

  • Acidosis / urine*
  • Adult
  • Child
  • Child, Preschool
  • Chromatography, Gas
  • Female
  • Humans
  • Hydroxy Acids / urine*
  • Hydroxybutyrates / urine
  • Infant
  • Keto Acids / urine
  • Lactates / urine
  • Male
  • Mass Spectrometry
  • Valerates / urine*

Substances

  • Hydroxy Acids
  • Hydroxybutyrates
  • Keto Acids
  • Lactates
  • Valerates