Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men

Acta Neurol Scand. 1995 Oct;92(4):297-8. doi: 10.1111/j.1600-0404.1995.tb00132.x.


An association between late-onset Alzheimer's disease, vascular dementia and the common polymorphic alleles of the gene coding for apolipoprotein E, epsilon 2, epsilon 3, and epsilon 4, was assessed in a population sample of 393 elderly Finnish men aged 70 to 89 years. Of them, 7% suffered Alzheimer's disease and 3% had vascular dementia. Among those who suffered Alzheimer's disease, there was a statistically significant excess of the epsilon 4 allele. No such an association was observed between the apolipoprotein E alleles and vascular dementia. We conclude that the apolipoprotein E polymorphism confers information about a risk of Alzheimer's disease in this population sample of elderly Finnish men.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged*
  • Alleles
  • Alzheimer Disease / genetics*
  • Apolipoproteins E / genetics*
  • Dementia, Vascular / genetics*
  • Finland
  • Humans
  • Male
  • Phenotype
  • Polymorphism, Genetic / genetics*


  • Apolipoproteins E