The systemic effect of intraarticular administration of corticosteroid on markers of bone formation and bone resorption in patients with rheumatoid arthritis

Arthritis Rheum. 1996 Feb;39(2):277-82. doi: 10.1002/art.1780390215.


Objective: To assess the effects of intraarticular (IA) corticosteroid use on bone metabolism in patients with rheumatoid arthritis (RA).

Methods: Levels of the bone turnover markers, serum osteocalcin (BGP) and urinary pyridinoline (PYD), were monitored in RA patients for 4 weeks following a single IA administration of xylocaine alone or in combination with triamcinolone acetonide.

Results: Levels of the bone resorption marker, PYD, did not show any significant change, whereas BGP levels were drastically decreased 1 day after IA administration of corticosteroid, and then returned to pretreatment levels by day 14. The efficacy of IA corticosteroid treatment lasted for 4 weeks.

Conclusion: Our results suggest that IA administration of corticosteroid has no net effects on bone resorption and only a transient systemic effect on bone formation. IA corticosteroid administration may be better for bone metabolism than continuous use of orally administered corticosteroid.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Amino Acids / urine
  • Anti-Inflammatory Agents / therapeutic use
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / physiopathology*
  • Biomarkers
  • Bone Resorption
  • Bone and Bones / metabolism*
  • Drug Combinations
  • Female
  • Humans
  • Injections, Intra-Articular
  • Lidocaine / therapeutic use
  • Male
  • Middle Aged
  • Osteocalcin / blood
  • Osteogenesis / drug effects*
  • Triamcinolone Acetonide / therapeutic use*


  • Amino Acids
  • Anti-Inflammatory Agents
  • Biomarkers
  • Drug Combinations
  • Osteocalcin
  • pyridinoline
  • Lidocaine
  • Triamcinolone Acetonide