The effect of chloroform-extractable secondary metabolites of filamentous fungi on the movement of respiratory tract cilia of one-day-old chicks in vitro

Folia Microbiol (Praha). 1995;40(1):123-7. doi: 10.1007/BF02816536.

Abstract

The ciliostatic activity of the chloroform-extractable metabolites of 72 strains of filamentous fungi growing in a liquid medium, on tracheal cilia from 1-d-old chicks in vitro was evaluated. Forty-eight of the investigated strains produced ciliostatic metabolites; 13, 11, 16, and 25% of the strains stopped the movement of cilia after 1, 2, 3, 6 d, respectively. The results are discussed in relationship with chronic bronchitis of people working with mouldy materials, living in mouldy dwellings and with the "sick-building syndrome".

MeSH terms

  • Animals
  • Animals, Newborn
  • Chickens
  • Chloroform
  • Cilia / drug effects*
  • Cilia / physiology*
  • Fungi / metabolism*
  • Fungi / pathogenicity*
  • Humans
  • In Vitro Techniques
  • Mycotoxins / isolation & purification
  • Mycotoxins / toxicity*
  • Respiratory System / drug effects*
  • Respiratory System / physiopathology*
  • Sick Building Syndrome / etiology
  • Trachea / drug effects
  • Trachea / physiopathology

Substances

  • Mycotoxins
  • Chloroform