Field trial of inactivated oral cholera vaccines in Bangladesh: results from 5 years of follow-up

Vaccine. 1996 Feb;14(2):162-6. doi: 10.1016/0264-410x(95)00122-h.


To determine the protective efficacy (PE) of three doses of oral B subunit-killed whole cell (BS-WC) or killed whole cell-only (WC) vaccines against cholera, a clinical trial was conducted among 62285 children over 2 years and adult women in rural Bangladesh. During 5 years of follow-up, there were 144 cases of cholera in the BS-WC group (PE = 49%; P < 0.001), 150 in the WC group (PE = 47%; P < 0.001), and 283 in the K12 group. Protection by each vaccine was evident only during the first three years of follow-up; long-term protection of young children was observed only against classical but not El Tor cholera; 3-year protection against both cholera biotypes occurred among older persons, but at a higher level against classical cholera.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Age Factors
  • Bangladesh / epidemiology
  • Child
  • Child, Preschool
  • Cholera / epidemiology
  • Cholera / prevention & control*
  • Cholera Vaccines / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Longitudinal Studies
  • Vaccines, Inactivated / therapeutic use


  • Cholera Vaccines
  • Vaccines, Inactivated