Comparative diagnoses of twin zygosity by SSLP variant analysis, questionnaire, and dermatoglyphic analysis

Behav Genet. 1996 Jan;26(1):55-63. doi: 10.1007/BF02361159.


Zygosity diagnosis has been performed in 79 pairs of twins using three methods. Simple sequence repeat length polymorphism (SSLP) analysis allows an efficient classification (MZ or DZ) with only a few markers following a simplified technique of extraction and amplification. A method based on a full questionnaire completed by parents about twin similarity correctly classifies 97.46% of the pairs; 92.41% are correctly classified using only four questions as suggested by logistic regression analysis. The third method, using dermatoglyphic analyses, correctly classifies 86.76% of pairs. To lower the cost of DNA diagnosis we stress the possibility of limiting its use to pairs with scores in the overlap area between MZ and DZ twins with a validated questionnaire.

Publication types

  • Twin Study

MeSH terms

  • Child
  • Cohort Studies
  • Dermatoglyphics*
  • Female
  • France
  • Genetics, Population
  • Humans
  • Male
  • Repetitive Sequences, Nucleic Acid / genetics*
  • Sequence Analysis, DNA*
  • Twins, Dizygotic / genetics*
  • Twins, Monozygotic / genetics*