Role of serotonin3 receptors in prolactin release induced by electroconvulsive therapy: a study with ondansetron

Psychiatry Res. 1996 Feb 28;60(1):33-9. doi: 10.1016/0165-1781(96)02892-2.

Abstract

The effect of pretreatment with odansetron on prolactin (PRL) release induced by electroconvulsive therapy (ECT) was examined in 16 depressive patients in a double-blind, placebo-controlled crossover study. Ten patients were pretreated with 4 mg and the other six with 8 mg of ondansetron. The order of administration of study medication (ondansetron and placebo) was counterbalanced. The failure of ondansetron to attenuate ECT-induced PRL release suggested that serotonin3 receptors are not involved in mediating this response.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Cross-Over Studies
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / therapy*
  • Double-Blind Method
  • Electroconvulsive Therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Ondansetron / pharmacology*
  • Ondansetron / therapeutic use*
  • Placebos
  • Prolactin / blood
  • Prolactin / metabolism*
  • Receptors, Serotonin / drug effects*
  • Serotonin / metabolism*
  • Serotonin Antagonists / pharmacology*
  • Serotonin Antagonists / therapeutic use*

Substances

  • Placebos
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Serotonin
  • Ondansetron
  • Prolactin