Stent redilation in canine models of congenital heart disease: pulmonary artery stenosis and coarctation of the aorta

Cathet Cardiovasc Diagn. 1996 Aug;38(4):430-40. doi: 10.1002/(SICI)1097-0304(199608)38:4<430::AID-CCD24>3.0.CO;2-H.


In a canine puppy model, pulmonary artery stenosis was created by banding the left pulmonary artery to 30-40% of its original diameter. Animals underwent right heart catheterization and angiography 1-2 mo later, and Palmaz P308 stents were implanted. Stent redilation was performed 3-5 mo later. One mo postredilation, the animals were restudied and sacrificed. Coarctations of the aorta were created by transverse aortic incision and longitudinal repair. P308 stent implantation was performed 2-3 mo later. Stent redilation was performed after 6-10 mo, and the animals were restudied and sacrificed 1-2 mo later. Stent implantation was performed in 6 puppies with pulmonary artery stenosis, as 2 animals developed postoperative pulmonary arterial hypoplasia, precluding stenting. The stenosis diameter increased from 4.8 +/- 0.5 mm to 7.4 +/- 0.6 mm (mean +/- SE) following stenting (P = 0.005), and increased further to 9.2 +/- 0.7 mm following redilation (P < 0.001). There were no significant vessel tears or ruptures. Coarctation stenting was performed in 8 animals. The coarctation was dilated from 5.8 +/- 0.9 mm to 9.8 +/- 0.6 mm (P < 0.001), and to 13.5 +/- 0.5 mm at redilation (P = 0.002). Redilation could not be performed in 1 animal. Aortic rupture and death occurred in 2 of 7 animals at redilation. Stent implantation and redilation in experimental pulmonary artery stenosis appears safe and effective. Though stent implantation for coarctation of the aorta appears safe, there was a 28% aortic rupture rate at stent redilation in this model.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angioplasty, Balloon*
  • Animals
  • Aortic Coarctation / diagnostic imaging
  • Aortic Coarctation / pathology
  • Aortic Coarctation / therapy*
  • Arterial Occlusive Diseases / diagnostic imaging
  • Arterial Occlusive Diseases / therapy*
  • Cardiac Catheterization
  • Dogs
  • Pulmonary Artery* / diagnostic imaging
  • Pulmonary Artery* / pathology
  • Radiography
  • Recurrence
  • Stents*