Imaging of dopamine transporters in humans with technetium-99m TRODAT-1

Eur J Nucl Med. 1996 Nov;23(11):1527-30. doi: 10.1007/BF01254479.


Technetium-99m TRODAT-1, a tropane derivative, has shown promise as a tracer for the imaging of dopamine transporters in preliminary studies in rats and baboons. The present report concerns the first study of the use of [99mTc]TRODAT-1 for the same purpose in humans. The specific uptake of [99mTc]TRODAT-1 in dopamine transporter sites located in the basal ganglia area was confirmed: the best contrast between the basal ganglia and the occipital area, which is devoid of dopamine transporters, was achieved at 120-140 min following injection. The development of a 99mTc-based agent bypasses the need for cyclotron-produced radionuclides, which will be of benefit for routine clinical studies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Basal Ganglia / diagnostic imaging
  • Basal Ganglia / metabolism
  • Brain / diagnostic imaging*
  • Brain / metabolism
  • Carrier Proteins / metabolism*
  • Dopamine / metabolism*
  • Dopamine Plasma Membrane Transport Proteins
  • Humans
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Nerve Tissue Proteins*
  • Organotechnetium Compounds*
  • Time Factors
  • Tomography, Emission-Computed, Single-Photon*
  • Tropanes*


  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Organotechnetium Compounds
  • Tropanes
  • technetium Tc 99m TRODAT-1
  • Dopamine