Analysis of serological surveys using mixture models: application to a survey of parvovirus B19

Stat Med. 1996 Jul 30;15(14):1567-73. doi: 10.1002/(SICI)1097-0258(19960730)15:14<1567::AID-SIM289>3.0.CO;2-G.

Abstract

A method for the analysis of age stratified antibody prevalence surveys is developed. The age specific distribution of the quantitative results of serological antibody tests is modelled as a mixture of seropositive and seronegative components. This yields maximum likelihood estimates of the prevalence at each age. The method is illustrated using data from a previously reported survey of antibody to parvovirus B19.

MeSH terms

  • Adolescent
  • Age Distribution
  • Antibodies, Viral / analysis
  • Child
  • Child, Preschool
  • Confidence Intervals
  • Enzyme-Linked Immunosorbent Assay
  • Health Surveys*
  • Humans
  • Infant
  • Infant, Newborn
  • Likelihood Functions
  • Models, Statistical*
  • Parvovirus B19, Human / immunology
  • Parvovirus B19, Human / isolation & purification*
  • Prevalence
  • Serologic Tests / statistics & numerical data*

Substances

  • Antibodies, Viral