Birth characteristics and risk of Wilms' tumour: a nationwide prospective study in Norway

Br J Cancer. 1996 Oct;74(7):1148-51. doi: 10.1038/bjc.1996.505.

Abstract

Relationships between incidence of Wilms' tumour and information recorded at birth were investigated in a prospective study of the 1,489,297 children born in Norway between 1967 and 1992. A total of 119 individuals were diagnosed with Wilms' tumour in the age interval 0-14 years. A high length at birth was significantly associated with a high risk (incidence rate ratio 1.8 for length > or = 53 cm vs < or = 49 cm, 95% CI 1.0-3.2). A low Apgar score at 1 min was also associated with an increased risk (incidence rate ratio 2.2 for Apgar score < or = 8 vs a score > or = 9, 95% CI 1.2-3.9). For all variables for which an association was indicated, the association seemed to be restricted mainly to children aged less than 2 years. This suggests that Wilms' tumour diagnosed early in life may differ aetiologically from that of cases diagnosed later.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age Factors
  • Apgar Score
  • Birth Weight
  • Body Constitution
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Gestational Age
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Kidney Neoplasms / epidemiology
  • Kidney Neoplasms / etiology*
  • Male
  • Norway / epidemiology
  • Prospective Studies
  • Risk Factors
  • Wilms Tumor / epidemiology
  • Wilms Tumor / etiology*