Antineutrophil cytoplasmic antibodies (ANCA)-associated crescentic glomerulonephritis and propylthiouracil therapy

Nephron. 1996;73(4):701-3. doi: 10.1159/000189164.

Abstract

Cutaneous vasculitis is an uncommon complication of propylthiouracil therapy. Although its pathogenesis remains to be established, detection of antineutrophil cytoplasmic antibodies (ANCA) in association with this type of vasculitis has recently been described. We report here 2 patients who developed ANCA-associated crescentic glomerulonephritis without evidence of cutaneous vasculitis during propylthiouracil treatment of hyperthyroidism. Improvement of the renal function and the disappearance of ANCA were correlately found after discontinuation of propylthiouracil and by corticosteroid therapy in both patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Antineutrophil Cytoplasmic / metabolism*
  • Antithyroid Agents / adverse effects*
  • Antithyroid Agents / therapeutic use
  • Female
  • Glomerulonephritis / chemically induced*
  • Glomerulonephritis / immunology
  • Glomerulonephritis / pathology
  • Humans
  • Hyperthyroidism / complications
  • Hyperthyroidism / drug therapy
  • Male
  • Middle Aged
  • Propylthiouracil / adverse effects*
  • Propylthiouracil / therapeutic use

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Antithyroid Agents
  • Propylthiouracil