Low dose melatonin improves sleep in healthy middle-aged subjects

Psychopharmacology (Berl). 1996 Jul;126(2):179-81. doi: 10.1007/BF02246354.

Abstract

We studied the effects of single evening doses of melatonin (0.3 mg and 1.0 mg orally) on polysomnographically measured sleep in 15 healthy middle-aged volunteers, using a placebo-controlled, double-blind, cross-over design. Compared to placebo, the 1.0 mg dose of melatonin significantly increased Actual Sleep Time, Sleep Efficiency, non-REM Sleep and REM Sleep Latency. These data are consistent with the hypothesis that low dose melatonin has hypnotic effects in humans. It is possible that administered melatonin may have a role to play in the treatment of sleep disorders.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Melatonin / pharmacology*
  • Middle Aged
  • Sleep / drug effects*
  • Sleep Stages / drug effects

Substances

  • Melatonin