DNA immunization

Trends Microbiol. 1996 Aug;4(8):307-12. doi: 10.1016/0966-842x(96)10048-2.


Inoculation with plasmid DNA vectors encoding immunogenic proteins induces both humoral and cell-mediated immune responses, which often provide protective immunity. Although many questions regarding the mechanism, efficacy and safety of DNA immunization remain to be addressed, this approach may offer a safer and more cost-effective alternative to conventional vaccines.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Communicable Disease Control / methods
  • Communicable Diseases / immunology
  • Drug Administration Routes
  • Drug Design
  • Genetic Vectors
  • Immunization / adverse effects
  • Immunization / methods*
  • Mice
  • Vaccines, DNA / immunology*


  • Vaccines, DNA