Treating major depression in primary care practice. Eight-month clinical outcomes

Arch Gen Psychiatry. 1996 Oct;53(10):913-9. doi: 10.1001/archpsyc.1996.01830100061008.


Background: We studied whether standardized treatments of major depression whose efficacy was established with psychiatric patients are equally effective when provided to primary care patients, and whether standardized treatments are more effective than a primary care physician's usual care.

Methods: A randomized controlled trial was conducted, in which primary care patients meeting DSM-III-R criteria for a current major depression were assigned to nortriptyline (n = 91) or interpersonal psychotherapy (n = 93) provided within well-structured parameters, or a physician's usual care (n = 92). The main outcome measures were degree and rate of improvement in severity of depressive symptoms and proportion of patients recovered at 8 months.

Results: Severity of depressive symptoms was reduced more rapidly and more effectively among patients randomized to pharmacotherapy or psychotherapy than among patients assigned to a physician's usual care. Among treatment completers, approximately 70% of patients participating in the full pharmacotherapy or psychotherapy protocol but only 20% of usual care patients were judged as recovered at 8 months.

Conclusions: Pharmacotherapy and psychotherapy effectively treat major depression among primary care patients when provided within specific parameters and for the full acute and continuation phases. Treatment principles recommended by the Depression Guideline Panel of the Agency for Health Care Policy and Research are supported.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Depressive Disorder / drug therapy
  • Depressive Disorder / psychology
  • Depressive Disorder / therapy*
  • Female
  • Health Policy
  • Humans
  • Male
  • Nortriptyline / therapeutic use*
  • Patient Dropouts
  • Practice Guidelines as Topic
  • Primary Health Care*
  • Psychiatric Status Rating Scales
  • Psychotherapy*
  • Severity of Illness Index
  • Treatment Outcome


  • Nortriptyline