Immunogenetic factors in HPV-associated cervical cancer: influence on disease progression

Eur J Immunogenet. 1996 Aug;23(4):275-84. doi: 10.1111/j.1744-313x.1996.tb00123.x.

Abstract

No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB1*1501/DQB1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Histocompatibility Testing*
  • Humans
  • Immunogenetics
  • Middle Aged
  • Papillomaviridae / classification*
  • Papillomaviridae / genetics
  • Papillomavirus Infections / immunology*
  • Papillomavirus Infections / virology
  • Tumor Virus Infections / immunology*
  • Tumor Virus Infections / virology
  • Uterine Cervical Neoplasms / immunology*
  • Uterine Cervical Neoplasms / virology