Uveitis associated with topical beta-blockers

Arch Ophthalmol. 1996 Oct;114(10):1181-2. doi: 10.1001/archopht.1996.01100140381002.


Objective: To assess the incidence of uveitis associated with topical beta-blockers.

Design: Retrospective cohort study.

Setting: A computerized database of a health maintenance organization was used to identify patients who were prescribed metipranolol or other beta-blockers.

Patients: Two groups: 1928 patients using 0.3% metipranolol and 3903 patients using other beta-blockers.

Main outcome measure: Cases of uveitis were identified by noting a prescription of a topical corticosteroid and then conducting a chart review.

Results: No cases of uveitis were identified among the 5831 patients. The upper limits of the 95% confidence intervals for the incidence of uveitis in cohorts of this size are 1.87 cases per 1000 person-years of exposure for metipranolol and 1.38 for other beta-blockers.

Conclusion: Drug-induced uveitis from metipranolol or other beta-blocker administration is a rare event, even if a causal relationship exists.

MeSH terms

  • Administration, Topical
  • Adrenergic beta-Antagonists / adverse effects*
  • Cohort Studies
  • Florida / epidemiology
  • Health Maintenance Organizations
  • Humans
  • Incidence
  • Metipranolol / adverse effects*
  • Ophthalmic Solutions
  • Retrospective Studies
  • Uveitis / chemically induced*
  • Uveitis / epidemiology*


  • Adrenergic beta-Antagonists
  • Ophthalmic Solutions
  • Metipranolol