Cytokine expression in the liver of mice infected with a highly virulent strain of Francisella tularensis

FEMS Immunol Med Microbiol. 1996 Mar;13(3):239-44. doi: 10.1111/j.1574-695X.1996.tb00244.x.


Cytokine mRNA expression was determined in the liver of mice subcutaneously inoculated with a lethal dose of the highly virulent strain FSC 041 of Francisella tularensis subvar, tularensis or a sublethal dose of the live vaccine strain of F. tularensis subvar. palaearctica. Expression of mRNA for TNF-alpha, IL-12, IFN-gamma, and IL-10 was demonstrated within 48 h of inoculation, the kinetics being similar irrespective of bacterial strain used. Thus, the expression of a cytokine response believed to be important in the early host defence against live vaccine strain seemed insufficient to prevent the lethality of a more virulent strain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cytokines / biosynthesis*
  • Cytokines / genetics
  • Female
  • Francisella tularensis / classification*
  • Francisella tularensis / immunology
  • Francisella tularensis / pathogenicity*
  • Liver / cytology
  • Liver / immunology*
  • Liver / metabolism*
  • Mice
  • Mice, Inbred BALB C
  • RNA, Messenger / biosynthesis
  • Species Specificity
  • Tularemia / immunology*
  • Virulence / immunology


  • Cytokines
  • RNA, Messenger