Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

Cell. 1996 Oct 18;87(2):175-85. doi: 10.1016/s0092-8674(00)81336-7.


The guidance of developing axons in the nervous system is mediated partly by diffusible chemoattractants secreted by axonal target cells. Netrins are chemoattractants for commissural axons in the vertebrate spinal cord, but the mechanisms through which they produce their effects are unknown. We show that Deleted in Colorectal Cancer (DCC), a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses netrin-1-binding activity. Moreover, an antibody to DCC selectively blocks the netrin-1-dependent outgrowth of commissural axons in vitro. These results indicate that DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons, and they complement genetic evidence for interactions between DCC and netrin homologs in C. elegans and Drosophila.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Axons / physiology
  • Base Sequence
  • Cell Adhesion Molecules / physiology*
  • Cells, Cultured
  • Gene Expression Regulation, Developmental
  • Genes, Tumor Suppressor
  • In Situ Hybridization
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Molecular Sequence Data
  • Nerve Growth Factors / physiology*
  • Netrin-1
  • Protein Binding
  • RNA, Messenger / genetics
  • Rats
  • Receptors, Cell Surface / genetics*
  • Recombinant Proteins
  • Signal Transduction
  • Spinal Cord / embryology
  • Spinal Cord / physiology
  • Tumor Suppressor Proteins*


  • Cell Adhesion Molecules
  • Membrane Proteins
  • Nerve Growth Factors
  • Ntn1 protein, rat
  • RNA, Messenger
  • Receptors, Cell Surface
  • Recombinant Proteins
  • Tumor Suppressor Proteins
  • neogenin
  • Netrin-1

Associated data

  • GENBANK/U68725
  • GENBANK/U68726