Antiphospholipid antibodies in patients with preeclampsia

Am J Reprod Immunol. 1996 Aug;36(2):81-5. doi: 10.1111/j.1600-0897.1996.tb00143.x.


Problem: To determine the incidence of anticardiolipin and antiphosphatidylserine antibodies in women with preeclampsia.

Methods: Sera from 100 women with preeclampsia and 100 normotensive pregnant women in the third trimester were assayed for anticardiolipin and antiphosphatidylserine antibodies.

Results: Antiphosphatidylserine antibodies were positive for IgM in 1 patient (1%) and for IgG in 4 patients (4%). IgM antibodies to cardiolipin were positive in two patients (2%) while IgG antibodies to cardiolipin were positive in nine patients (9%). Only 3% of the control women were positive for antiphospholipid antibodies. None of the patients or controls had positive levels of IgA anticardiolipin or antiphosphatidylserine antibodies.

Conclusions: Elevated levels of IgG or IgM antibodies to cardiolipin and phosphatidylserine were detected in 11/100 (11%) of women diagnosed with preeclampsia in the third trimester compared to only 3/100 (3%) positive in controls (P < or = 0.05). These findings suggest that antiphospholipid antibodies may play a pathogenic role in some women with preeclampsia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Anticardiolipin / analysis
  • Antibodies, Anticardiolipin / immunology
  • Antibodies, Antiphospholipid / analysis*
  • Antibodies, Antiphospholipid / immunology
  • Female
  • Humans
  • Phosphatidylserines / immunology
  • Pre-Eclampsia / immunology*
  • Pregnancy


  • Antibodies, Anticardiolipin
  • Antibodies, Antiphospholipid
  • Phosphatidylserines