Abstract
Antisense oligomers (18 mers) corresponding to the erythropoietin and erythropoietin receptor 5' coding sequences cause marked suppression of proliferation of several lines of erythroleukemic cells. In these systems, phosphorothioate protected sense oligomers are inhibitory, while the unmodified sense oligomers have no significant effect on cell growth. These data indicate that proliferation of some erythroleukemic cells is under internal autocrine regulation by erythropoietin and its receptor.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Cell Division / drug effects
-
Erythropoietin / antagonists & inhibitors
-
Erythropoietin / metabolism*
-
Friend murine leukemia virus*
-
Leukemia, Erythroblastic, Acute / metabolism
-
Leukemia, Erythroblastic, Acute / pathology*
-
Mice
-
Oligonucleotides, Antisense / pharmacology*
-
Receptors, Erythropoietin / antagonists & inhibitors
-
Receptors, Erythropoietin / metabolism*
-
Thionucleotides / pharmacology*
-
Tumor Cells, Cultured
Substances
-
Oligonucleotides, Antisense
-
Receptors, Erythropoietin
-
Thionucleotides
-
Erythropoietin