Elevated venous glutamate levels in (pre)catabolic conditions result at least partly from a decreased glutamate transport activity

J Mol Med (Berl). 1996 Jun;74(6):337-43. doi: 10.1007/BF00207511.

Abstract

Abnormally high postabsorptive venous plasma glutamate levels have been reported for several diseases that are associated with a loss of body cell mass including cancer, human/simian immunodeficiency virus infection, and amyotrophic lateral sclerosis. Studies on exchange rates in well-nourished cancer patients now show that high venous plasma glutamate levels may serve as a bona fide indicator for a decreased uptake of glutamate by the peripheral muscle tissue in the postabsorptive period and may be indicative for a precachectic state. High glutamate levels are also moderately correlated with a decreased uptake of glucose and ketone bodies. Relatively high venous glutamate levels have also been found in non-insulin-dependent diabetes mellitus and to some extent also in the cubital vein of normal elderly subjects, i.e., in conditions commonly associated with a decreased glucose tolerance and progressive loss of body cell mass.

MeSH terms

  • ATP-Binding Cassette Transporters / metabolism*
  • Aged
  • Amino Acid Transport System X-AG
  • Biomarkers
  • Cachexia / blood*
  • Cachexia / etiology
  • Cations / metabolism
  • Diabetes Mellitus, Type 2 / complications
  • Eating
  • Female
  • Glucose / metabolism
  • Glutamates / blood*
  • Glutamates / physiology
  • Humans
  • Ketone Bodies / metabolism
  • Male
  • Middle Aged
  • Muscle, Skeletal / metabolism
  • Neoplasms / complications
  • Neoplasms / metabolism*
  • Sodium / metabolism
  • Veins

Substances

  • ATP-Binding Cassette Transporters
  • Amino Acid Transport System X-AG
  • Biomarkers
  • Cations
  • Glutamates
  • Ketone Bodies
  • Sodium
  • Glucose