Congenital erythrocyte enzyme deficiencies

Vet Clin North Am Small Anim Pract. 1996 Sep;26(5):1003-11. doi: 10.1016/s0195-5616(96)50052-5.

Abstract

Congenital hemolytic anemias resulting from PK, PFK, and G6PD enzyme deficiencies have been reported in domestic animals. Dogs with PFK deficiency may have episodes of intravascular hemolysis with hemoglobinuria in addition to a persistent compensated hemolytic anemia. Patients with mild G6PD deficiency are not anemic but may show increased susceptibility to oxidant-induced erythrocyte injury. Persistent methemoglobinemia has been reported in dogs and cats with methemoglobin reductase enzyme deficiency. Affected animals have cyanotic-appearing mucous membranes but show no or only mild clinical signs attributable to hypoxemia. Enzyme assays are usually done after acquired causes of hemolytic anemia and methemoglobinemia have been ruled out.

Publication types

  • Review

MeSH terms

  • Animals
  • Cat Diseases / blood*
  • Cat Diseases / congenital*
  • Cat Diseases / diagnosis
  • Cats
  • Cytochrome-B(5) Reductase / analysis
  • Cytochrome-B(5) Reductase / deficiency
  • Diagnosis, Differential
  • Dog Diseases / blood*
  • Dog Diseases / congenital*
  • Dog Diseases / diagnosis
  • Dogs
  • Erythrocytes / enzymology*
  • Glucosephosphate Dehydrogenase / analysis
  • Glucosephosphate Dehydrogenase Deficiency / blood
  • Glucosephosphate Dehydrogenase Deficiency / diagnosis
  • Glucosephosphate Dehydrogenase Deficiency / veterinary
  • Hematologic Diseases / congenital
  • Hematologic Diseases / enzymology
  • Hematologic Diseases / veterinary*
  • Metabolism, Inborn Errors / diagnosis
  • Metabolism, Inborn Errors / enzymology
  • Metabolism, Inborn Errors / veterinary*
  • Phosphofructokinase-1 / analysis
  • Phosphofructokinase-1 / deficiency
  • Pyruvate Kinase / analysis
  • Pyruvate Kinase / deficiency

Substances

  • Glucosephosphate Dehydrogenase
  • Cytochrome-B(5) Reductase
  • Phosphofructokinase-1
  • Pyruvate Kinase