Abstract
Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 microM. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Coumarins / isolation & purification*
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Coumarins / pharmacology
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DNA-Directed RNA Polymerases / antagonists & inhibitors
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HIV Reverse Transcriptase / antagonists & inhibitors*
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HIV-1 / enzymology*
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Humans
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Indicators and Reagents
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Latex / chemistry
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Nucleic Acid Synthesis Inhibitors
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Plants, Medicinal / chemistry*
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Reverse Transcriptase Inhibitors / isolation & purification
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Reverse Transcriptase Inhibitors / pharmacology*
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Ribonuclease H / antagonists & inhibitors
Substances
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Coumarins
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Indicators and Reagents
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Latex
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Nucleic Acid Synthesis Inhibitors
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Reverse Transcriptase Inhibitors
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soulattrolide
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HIV Reverse Transcriptase
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DNA-Directed RNA Polymerases
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Ribonuclease H