Lack of a temporal gradient of retrograde amnesia following NMDA-induced lesions of the basolateral amygdala assessed with the fear-potentiated startle paradigm

Behav Neurosci. 1996 Aug;110(4):836-9. doi: 10.1037//0735-7044.110.4.836.


M. Kim and M. Davis (1993b) previously reported that electrolytic lesions of the central nucleus of the amygdala, made 6 or 30 days after training, completely blocked the expression of fear-potentiated startle in rats. The present study shows that excitotoxic lesions of the basolateral amygdala also block fear-potentiated startle and do so whether the lesions are made soon (i.e., 6 days) or long (i.e., 30 days) after training. The relevance of these findings to various theories of amygdala function is discussed.

MeSH terms

  • Amygdala / physiology*
  • Animals
  • Association Learning / physiology
  • Avoidance Learning / physiology
  • Brain Mapping
  • Conditioning, Classical / physiology*
  • Fear / physiology*
  • Male
  • Mental Recall / physiology*
  • N-Methylaspartate / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Reflex, Startle / physiology*
  • Retention, Psychology / physiology


  • N-Methylaspartate