Inhibition of catechol O-methyltransferase and transfer RNA methyltransferases by coralyne, nitidine, and related compounds

J Pharm Sci. 1977 Jul;66(7):986-9. doi: 10.1002/jps.2600660721.

Abstract

Inhibitory activity against both catechol O-methyltransferase and transfer RNA methyltransferases was observed among the antileukemic alkaloids coralyne, nitidine, and related synthetic alkoxy analogs. Inhibition of both classes of enzymes seems to have a similar profile. The role of water solubility of these compounds with regard to their enzyme inhibitory activity was noted.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Benzophenanthridines
  • Berberine Alkaloids / pharmacology*
  • Catechol O-Methyltransferase Inhibitors*
  • In Vitro Techniques
  • Liver / enzymology
  • Male
  • Phenanthridines / pharmacology*
  • Rats
  • Solubility
  • tRNA Methyltransferases / antagonists & inhibitors*

Substances

  • Antineoplastic Agents, Phytogenic
  • Benzophenanthridines
  • Berberine Alkaloids
  • Catechol O-Methyltransferase Inhibitors
  • Phenanthridines
  • coralyne
  • nitidine
  • tRNA Methyltransferases