Abstract
Inhibitory activity against both catechol O-methyltransferase and transfer RNA methyltransferases was observed among the antileukemic alkaloids coralyne, nitidine, and related synthetic alkoxy analogs. Inhibition of both classes of enzymes seems to have a similar profile. The role of water solubility of these compounds with regard to their enzyme inhibitory activity was noted.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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Benzophenanthridines
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Berberine Alkaloids / pharmacology*
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Catechol O-Methyltransferase Inhibitors*
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In Vitro Techniques
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Liver / enzymology
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Male
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Phenanthridines / pharmacology*
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Rats
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Solubility
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tRNA Methyltransferases / antagonists & inhibitors*
Substances
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Antineoplastic Agents, Phytogenic
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Benzophenanthridines
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Berberine Alkaloids
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Catechol O-Methyltransferase Inhibitors
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Phenanthridines
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coralyne
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nitidine
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tRNA Methyltransferases