Ampicillin/sulbactam vs. clindamycin/gentamicin in the treatment of postpartum endometritis

J Reprod Med. 1996 Aug;41(8):575-80.


Objective: To evaluate the efficacy and safety of ampicillin/sulbactam with those of clindamycin/gentamicin.

Study design: A prospective, randomized clinical trial of patients with the diagnosis of postpartum endometritis. Intravenous ampicillin, 2.0 g, combined with 1.0 g sulbactam was administered every six hours or intravenous clindamycin, 900 mg, plus gentamicin, 1.5 mg/kg (not to exceed 150 mg unless gentamicin levels were obtained) every eight hours. Endometrial and blood specimens were obtained for culture and antibiotic susceptibility testing.

Results: One hundred twenty-nine hospitalized women with the diagnosis of endometritis were enrolled. Both treatment regimens were equally effective. At the end of treatment, 42 of 51 (82%) ampicillin/sulbactam-treated patients achieved clinical cure in comparison to 47 of 56 (84%) patients in the clindamycin/gentamicin group. Respective bacterial eradication rates of 86% and 84% for each treatment group were seen. Both antibiotic regimens were well tolerated, with no statistically significant difference in the incidence of adverse experiences.

Conclusion: The two antibiotic regimens were equally effective for a clinical cure, bacterial eradication and incidence of adverse experiences.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Ampicillin / therapeutic use*
  • Anti-Bacterial Agents / therapeutic use*
  • Clindamycin / therapeutic use*
  • Drug Therapy, Combination / therapeutic use*
  • Endometritis / drug therapy*
  • Endometritis / microbiology
  • Female
  • Gentamicins / therapeutic use*
  • Humans
  • Microbial Sensitivity Tests
  • Penicillins / therapeutic use*
  • Prospective Studies
  • Puerperal Infection / drug therapy*
  • Puerperal Infection / microbiology
  • Sulbactam / therapeutic use*
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Gentamicins
  • Penicillins
  • Clindamycin
  • Ampicillin
  • Sulbactam