Inducing properties of rifabutin, and effects on the pharmacokinetics and metabolism of concomitant drugs

Pharmacol Res. 1995 Oct;32(4):177-87. doi: 10.1016/s1043-6618(05)80021-0.


Rifabutin, a rifamycin derivative like rifampicin, has been registered for the treatment of pulmonary tuberculosis and for the prophylaxis and treatment of MAC in patients with AIDS. Rifabutin induces cytochrome P-450 3A4. The effect of rifabutin on the pharmacokinetics and metabolism of drugs administered concomitantly to humans (isoniazid, ethambutol, zidovudine, didanosine, delavirdine, fluconazole, itraconazole, methadone, clarithromycin, theophylline and cyclosporin) has been reviewed.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy
  • Humans
  • Isoniazid / pharmacology
  • Rifabutin / pharmacokinetics*
  • Tuberculosis / drug therapy


  • Rifabutin
  • Isoniazid