Aversive effects of the synthetic cannabinoid CP 55,940 in rats

Pharmacol Biochem Behav. 1996 Mar;53(3):657-64. doi: 10.1016/0091-3057(95)02066-7.


A series of experiments investigated the behavioral and hedonic effects of the synthetic cannabinoid CP 55,940 in male Wistar rats. CP 55,940 had a biphasic effect on locomotor activity, with a 10 micrograms/kg dose causing locomotor stimulation and a 100 micrograms/kg dose causing profound hypoactivity. CP 55,940 (100 micrograms/kg) also caused a marked hypothermia for at least 3 h following administration, while lower doses (2.5 and 10 micrograms/kg) had no effect. CP 55,940 (100 micrograms/kg) had anorexic and hyperdipsic effects for up to 24 h following administration and caused significant reductions in body weight. CP 55,940 (100 micrograms/kg) also caused significant avoidance to a flavoured fluid (saccharin) with which it was paired. In the conditioned place preference paradigm both the 10 micrograms/kg and 100 micrograms/kg doses of CP 55,940 produced significant place avoidance. It is concluded that CP 55,940 is aversive to rats. The possible mechanisms underlying this aversion are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / pharmacology*
  • Animals
  • Avoidance Learning / drug effects*
  • Behavior, Animal / drug effects
  • Body Temperature / drug effects
  • Cyclohexanols / pharmacology*
  • Locomotion / drug effects
  • Male
  • Rats
  • Rats, Wistar
  • Taste / drug effects*
  • Time Factors


  • Analgesics
  • Cyclohexanols
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol