A controlled clinical investigation of 3% diclofenac/2.5% sodium hyaluronate topical gel in the treatment of uncontrolled pain in chronic oral NSAID users with osteoarthritis

Int J Tissue React. 1995;17(4):129-32.

Abstract

Topical application, 4 times daily for 2 weeks, of the diclofenac-hyaluronan gel to 59 osteoarthritis patients induced a significantly greater (p = 0.057) analgesic effect than placebo gel lacking the active substance applied to 60 control patients.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Administration, Topical
  • Analgesics / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Diclofenac / therapeutic use*
  • Gels
  • Humans
  • Hyaluronic Acid / therapeutic use*
  • Osteoarthritis / drug therapy*
  • Osteoarthritis / physiopathology
  • Pain
  • Palliative Care*
  • Time Factors
  • Treatment Outcome

Substances

  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Gels
  • Diclofenac
  • Hyaluronic Acid