The role of MCM proteins in the cell cycle control of genome duplication

Bioessays. 1996 Mar;18(3):183-90. doi: 10.1002/bies.950180305.


The regulatory mechanism which ensures that eukaryotic chromosomes replicate precisely once per cell cycle is a basic and essential cellular property of eukaryotes. This fundamental aspect of DNA replication is still poorly understood, but recent advances encourage the view that we may soon have a clearer picture of how this regulation is achieved. This review will discuss in particular the role of proteins in the minichromosome maintenance (MCM) family, which may hold the key to understanding how DNA is replicated once, and only once, per cell cycle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism*
  • Chromosomes / genetics
  • Chromosomes / metabolism
  • DNA Replication / genetics
  • DNA Replication / physiology*
  • Nuclear Proteins / metabolism
  • Xenopus


  • Cell Cycle Proteins
  • Nuclear Proteins