In vitro evaluation of N-(fluoro)isopropyl norephedrine as potential cardiac imaging agents for PET

Nucl Med Biol. 1996 Feb;23(2):155-7. doi: 10.1016/0969-8051(95)02048-9.

Abstract

N-Isopropylnorephedrine (INE) and N-fluoroisopropylnorephedrine (FINE) were found to have a poor affinity for either beta-adrenoceptors and the norepinephrine carrier protein. The low affinity of both compounds for Uptake-1 is probably due to the introduction of a bulky substituent on the nitrogen atom. It is concluded that INE and FINE cannot be used for cardiac imaging with PET.

MeSH terms

  • 3-Iodobenzylguanidine
  • Animals
  • Carrier Proteins / metabolism
  • Heart / diagnostic imaging*
  • Humans
  • Iodobenzenes / metabolism
  • Ligands
  • Myocardium / metabolism*
  • PC12 Cells
  • Phenylpropanolamine / analogs & derivatives*
  • Phenylpropanolamine / pharmacokinetics
  • Rats
  • Receptors, Adrenergic, alpha / metabolism
  • Receptors, Adrenergic, beta / metabolism
  • Tomography, Emission-Computed
  • Tumor Cells, Cultured

Substances

  • Carrier Proteins
  • Iodobenzenes
  • Ligands
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic, beta
  • N-fluoroisopropylnorephedrine
  • Phenylpropanolamine
  • 3-Iodobenzylguanidine