Abstract
N-Isopropylnorephedrine (INE) and N-fluoroisopropylnorephedrine (FINE) were found to have a poor affinity for either beta-adrenoceptors and the norepinephrine carrier protein. The low affinity of both compounds for Uptake-1 is probably due to the introduction of a bulky substituent on the nitrogen atom. It is concluded that INE and FINE cannot be used for cardiac imaging with PET.
MeSH terms
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3-Iodobenzylguanidine
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Animals
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Carrier Proteins / metabolism
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Heart / diagnostic imaging*
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Humans
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Iodobenzenes / metabolism
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Ligands
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Myocardium / metabolism*
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PC12 Cells
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Phenylpropanolamine / analogs & derivatives*
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Phenylpropanolamine / pharmacokinetics
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Rats
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Receptors, Adrenergic, alpha / metabolism
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Receptors, Adrenergic, beta / metabolism
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Tomography, Emission-Computed
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Tumor Cells, Cultured
Substances
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Carrier Proteins
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Iodobenzenes
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Ligands
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Receptors, Adrenergic, alpha
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Receptors, Adrenergic, beta
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N-fluoroisopropylnorephedrine
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Phenylpropanolamine
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3-Iodobenzylguanidine