Identification of sodC encoding periplasmic [Cu,Zn]-superoxide dismutase in Salmonella

FEMS Microbiol Lett. 1996 Feb 15;136(2):215-20. doi: 10.1111/j.1574-6968.1996.tb08052.x.

Abstract

sodC, encoding [Cu,Zn]-cofactored superoxide dismutase, once thought to be virtually confined to eukaryotes, has now been described in many Gram-negative pathogens that have their primary niche of colonization in the upper respiratory tract. Their role in host-parasite interactive biology is unknown. We here show that members of the major human and animal enteric pathogenic species Salmonella harbour a version of sodC most closely resembling that found in Brucella abortus. The enzyme it encodes is a novel candidate determinant of virulence in Salmonella, an intracellular pathogen potentially exposed to toxic oxygen free radicals within its intracellular niche.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Southern
  • Brucella abortus / genetics
  • Caulobacter crescentus / genetics
  • DNA Primers / genetics
  • Haemophilus / genetics
  • Molecular Sequence Data
  • Photobacterium / genetics
  • Polymerase Chain Reaction
  • Salmonella / enzymology*
  • Salmonella / genetics
  • Salmonella / pathogenicity
  • Sequence Homology, Amino Acid
  • Superoxide Dismutase / genetics*
  • Virulence

Substances

  • DNA Primers
  • Superoxide Dismutase

Associated data

  • GENBANK/X94327