The multiple roles of transcription/repair factor TFIIH

Trends Biochem Sci. 1996 Sep;21(9):346-50.


TFIIH is by far the most complex of the basal RNA polymerase II transcription factors. It is a protein kinase, a bi-directional DNA helicase and is essential for both transcription and nucleotide excision repair (NER). Furthermore, the factor can activate cyclin-dependent kinases and so might play a role in cell-cycle regulation. The recent elucidation of the subunit composition of TFIIH has shown an extraordinary conservation of its structure from yeast to human.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Binding Sites
  • Cyclin-Dependent Kinases / metabolism
  • DNA Helicases / metabolism
  • DNA Repair*
  • Enzyme Activation
  • Humans
  • Phosphorylation
  • RNA Polymerase II / metabolism
  • Transcription Factor TFIIH
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription Factors / physiology*
  • Transcription Factors, TFII*
  • Transcription, Genetic*


  • Transcription Factors
  • Transcription Factors, TFII
  • transcription factor TFIIE
  • Transcription Factor TFIIH
  • Adenosine Triphosphate
  • Cyclin-Dependent Kinases
  • RNA Polymerase II
  • DNA Helicases