Lymphoproliferative disorders in Sotos syndrome: observation of two cases

Am J Med Genet. 1996 Sep 6;64(4):588-93. doi: 10.1002/(SICI)1096-8628(19960906)64:4<588::AID-AJMG12>3.0.CO;2-D.


Sotos syndrome is included among the overgrowth disorders, most of which have an increased risk of neoplasms. Sotos syndrome does not appear to be related to a specific tumor type, but rather to the development of solid tumors of ectodermal or mesodermal origin in general. We report on two Sotos syndrome patients who developed a non-Hodgkin lymphoma and an acute lymphoblastic leukaemia, respectively. Our experience suggests that there may exist a high frequency of lymphoproliferative disorders in Sotos syndrome, and points out the importance of a long-term follow-up of Sotos syndrome patients, to detect a possible neoplastic evolution.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / genetics*
  • Brain / abnormalities
  • Child, Preschool
  • Growth Disorders / complications
  • Growth Disorders / genetics
  • Humans
  • Lymphoproliferative Disorders / complications*
  • Male
  • Skull / abnormalities
  • Syndrome