Histopathology of subacute renal lesions in mice induced by streptozotocin

Exp Toxicol Pathol. 1995 Dec;47(6):485-91. doi: 10.1016/s0940-2993(11)80332-5.


Streptozotocin (SZ) was inoculated intraperitoneally to male and female mice of ICR and BALB/c strains in a different way of administration (A: single injection and B consecutive 5 days-injection) and subacute renal changes were examined light and electron microscopically 8 weeks after SZ-administration. The following changes were detected: (1) reduction in the rate of male-type Bowman's capsules in male mice, (2) karyocytomegaly of proximal tubular epithelial cells, and (3) dilation of distal tubules Tubular changes were detected with high incidence in A (males and females) and B groups (males) of ICR strain.

MeSH terms

  • Animals
  • Female
  • Injections, Intraperitoneal
  • Kidney / drug effects*
  • Kidney / pathology*
  • Kidney / ultrastructure
  • Kidney Diseases / pathology*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred ICR
  • Streptozocin / administration & dosage
  • Streptozocin / toxicity*


  • Streptozocin