Rho family GTPases: the cytoskeleton and beyond

Trends Biochem Sci. 1996 May;21(5):178-81.


Until recently, members of the Rho family of GTPases were considered primarily to be regulators of the distinct structures making up the actin cytoskeleton. Several Rho GTPases have now also been shown to play an important role in cell transformation. In addition, Cdc42, Rac and Rho activate transcription, providing a possible mechanism for their role in growth control.

Publication types

  • Review

MeSH terms

  • Actins / metabolism
  • Cell Adhesion
  • Cell Cycle*
  • Cytoskeleton / metabolism*
  • GTP-Binding Proteins / classification
  • GTP-Binding Proteins / metabolism*
  • Models, Biological


  • Actins
  • GTP-Binding Proteins