Longitudinal analysis of soluble intercellular adhesion molecule 1 in retinal vasculitis patients

Eur J Clin Invest. 1996 Aug;26(8):686-91. doi: 10.1111/j.1365-2362.1996.tb02154.x.


Increased levels of soluble intercellular adhesion molecule 1 (sICAM-1) in serum have been demonstrated in several human disease conditions. We have previously shown, in a point-prevalence study, a positive correlation between sICAM-1 levels and disease relapse in patients with idiopathic retinal vasculitis. We now report a longitudinal study over 1 year in which sICAM-1 levels were compared with clinical disease status in order to determine this relationship further. Serum samples from 11 patients with idiopathic retinal vasculitis were tested for the presence of sICAM-1 by enzyme linked immunosorbent assay. Eight control subjects were also tested. Five out of 11 patients presented with relapse and had raised sICAM-1 levels compared with quiescent periods of their disease. Five out of 11 patients showed no relapse over 1 year and also no increase in sICAM-1 levels. One patient showed increased levels of sICAM-1, but no clinical signs of relapse. These results indicate that sICAM-1 is associated with disease activity in retinal vasculitis patients and could indicate dysfunction of the blood-retina barrier.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / blood
  • Anti-Inflammatory Agents / pharmacology
  • Biomarkers
  • Female
  • Humans
  • Intercellular Adhesion Molecule-1 / analysis
  • Intercellular Adhesion Molecule-1 / metabolism*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Prednisolone / blood
  • Prednisolone / pharmacology
  • Recurrence
  • Retina / metabolism
  • Vasculitis / metabolism*


  • Anti-Inflammatory Agents
  • Biomarkers
  • Intercellular Adhesion Molecule-1
  • Prednisolone