Abstract
Granule cells of the dentate gyrus can express neuropeptide-Y (NPY) in several models of epilepsy involving limbic seizures, however, the nature of this ectopic expression is not well understood at present. We have studied the expression of NPY-immunoreactivity in mossy fibres contralateral to a unilateral intrahippocampal injection of kainic acid and report that ectopic mossy fibre NPY-immunoreactivity is observed throughout the contralateral hippocampus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibody Specificity
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Epilepsy / physiopathology
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Excitatory Amino Acid Agonists / pharmacology*
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Hippocampus / chemistry*
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Hippocampus / cytology
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Hippocampus / drug effects
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Immunohistochemistry
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Kainic Acid / pharmacology*
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Male
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Microinjections
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Neuropeptide Y / analysis
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Neuropeptide Y / immunology*
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Rats
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Rats, Wistar
Substances
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Excitatory Amino Acid Agonists
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Neuropeptide Y
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Kainic Acid