Widespread ectopic neuropeptide-Y immunoreactivity in contralateral mossy fibres after a unilateral intrahippocampal kainic acid injection in the rat

Neurosci Lett. 1996 Aug 9;213(3):181-4. doi: 10.1016/0304-3940(96)12854-8.

Abstract

Granule cells of the dentate gyrus can express neuropeptide-Y (NPY) in several models of epilepsy involving limbic seizures, however, the nature of this ectopic expression is not well understood at present. We have studied the expression of NPY-immunoreactivity in mossy fibres contralateral to a unilateral intrahippocampal injection of kainic acid and report that ectopic mossy fibre NPY-immunoreactivity is observed throughout the contralateral hippocampus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibody Specificity
  • Epilepsy / physiopathology
  • Excitatory Amino Acid Agonists / pharmacology*
  • Hippocampus / chemistry*
  • Hippocampus / cytology
  • Hippocampus / drug effects
  • Immunohistochemistry
  • Kainic Acid / pharmacology*
  • Male
  • Microinjections
  • Neuropeptide Y / analysis
  • Neuropeptide Y / immunology*
  • Rats
  • Rats, Wistar

Substances

  • Excitatory Amino Acid Agonists
  • Neuropeptide Y
  • Kainic Acid