In-vitro activity of ofloxacin, levofloxacin and D-ofloxacin against staphylococci

J Antimicrob Chemother. 1996 Aug;38(2):259-63. doi: 10.1093/jac/38.2.259.


The in-vitro activity of levofloxacin was compared with ofloxacin and D-ofloxacin against 130 isolates of Staphylococcus aureaus and 117 isolates of coagulase-negative staphylococci, using the agar dilution method. In general, levofloxacin was equally active or up to fourfold more active than ofloxacin against all staphylococci, including 61 methicillin-resistant S. aureus. In contrast, D-ofloxacin showed little activity against all isolates tested.

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Drug Resistance, Microbial
  • Levofloxacin*
  • Microbial Sensitivity Tests
  • Ofloxacin / pharmacology*
  • Staphylococcus / drug effects*
  • Staphylococcus aureus / drug effects*
  • Stereoisomerism


  • Anti-Infective Agents
  • Levofloxacin
  • Ofloxacin