Regulation of interferon-gamma gene expression

J Interferon Cytokine Res. 1996 Aug;16(8):563-8. doi: 10.1089/jir.1996.16.563.

Abstract

Interferon-gamma (IFN-gamma), also known as type II interferon, is an important immunoregulatory gene that has multiple effects on the development, maturation, and function of the immune system. IFN-gamma mRNA and protein are expressed predominantly by T cells and large granular lymphocytes. The IFN-gamma mRNA is induced/inhibited in these cell types by a wide variety of extracellular signals, thus implicating a number of diverse, yet convergent signal transduction pathways in its transcriptional control. In this review, I describe how DNA methylation and specific DNA binding proteins may regulate transcription of the IFN-gamma gene in response to extracellular signals.

Publication types

  • Review

MeSH terms

  • Animals
  • Cyclosporine / pharmacology
  • DNA / chemistry
  • DNA / genetics
  • DNA-Binding Proteins / physiology
  • Enhancer Elements, Genetic
  • Erythroid-Specific DNA-Binding Factors
  • Gene Expression Regulation* / drug effects
  • Glucocorticoids / pharmacology
  • Humans
  • Interferon-gamma / biosynthesis
  • Interferon-gamma / genetics*
  • Ionomycin / pharmacology
  • Leukemia-Lymphoma, Adult T-Cell / pathology
  • Lymphocyte Activation
  • Lymphocyte Subsets / drug effects
  • Lymphocyte Subsets / metabolism*
  • Methylation
  • Mice
  • NF-kappa B / physiology
  • Phytohemagglutinins / pharmacology
  • Promoter Regions, Genetic / drug effects
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • T-Lymphocytes / metabolism
  • Tetradecanoylphorbol Acetate / pharmacology
  • Transcription Factors / physiology
  • Transcription, Genetic
  • Tumor Cells, Cultured

Substances

  • DNA-Binding Proteins
  • Erythroid-Specific DNA-Binding Factors
  • Glucocorticoids
  • NF-kappa B
  • Phytohemagglutinins
  • RNA, Messenger
  • Transcription Factors
  • Ionomycin
  • Interferon-gamma
  • Cyclosporine
  • DNA
  • Tetradecanoylphorbol Acetate