Abstract
Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease that occurs in immunocompromised hosts. We describe two patients with biopsy-proved PML who showed improvement clinically and radiologically after medical therapy. These cases reveal that interval improvement can in rare instances be consistent with a diagnosis of PML.
MeSH terms
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Adult
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Brain / pathology
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Cytarabine / therapeutic use*
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Drug Therapy, Combination
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Female
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Humans
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Immunization, Passive*
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Interferon-alpha / therapeutic use*
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Leukoencephalopathy, Progressive Multifocal / diagnosis*
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Leukoencephalopathy, Progressive Multifocal / physiopathology
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Leukoencephalopathy, Progressive Multifocal / therapy*
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Magnetic Resonance Imaging*
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Male
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Middle Aged
Substances
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Interferon-alpha
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Cytarabine