Progressive multifocal leukoencephalopathy: clinical and MR response to treatment

AJNR Am J Neuroradiol. 1996 Mar;17(3):597-600.

Abstract

Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease that occurs in immunocompromised hosts. We describe two patients with biopsy-proved PML who showed improvement clinically and radiologically after medical therapy. These cases reveal that interval improvement can in rare instances be consistent with a diagnosis of PML.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Brain / pathology
  • Cytarabine / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immunization, Passive*
  • Interferon-alpha / therapeutic use*
  • Leukoencephalopathy, Progressive Multifocal / diagnosis*
  • Leukoencephalopathy, Progressive Multifocal / physiopathology
  • Leukoencephalopathy, Progressive Multifocal / therapy*
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged

Substances

  • Interferon-alpha
  • Cytarabine