Drug-related Henoch-Schönlein Purpura

Allergol Immunopathol (Madr). Jan-Feb 1996;24(1):22-4.


We report the case of a patient with Henoch-Schönlein Purpura related to a treatment with cefuroxime and diclofenac who presented important systemic manifestations including a glomerulonephritis with IgA mesangial deposits. Skin testing with beta lactam antibiotics and diclofenac were negative in immediate and late reaction as well as RAST test to penicillins G and V. No cautious administration of drugs was done because of the illness severity. Although a reaction to diclofenac could not be excluded we thought that the more probably implicated drug was cefuroxime because the patient referred a purpuric rash after the intake of cephradine for a mastitis, ten years ago.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Cefuroxime / administration & dosage
  • Cefuroxime / adverse effects*
  • Cephalosporins / administration & dosage
  • Cephalosporins / adverse effects*
  • Diclofenac / administration & dosage
  • Diclofenac / adverse effects*
  • Drug Therapy, Combination
  • Female
  • Hematuria / chemically induced
  • Humans
  • Mastitis / drug therapy
  • Proteinuria / chemically induced
  • Purpura, Schoenlein-Henoch / chemically induced*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Cephalosporins
  • Diclofenac
  • Cefuroxime