The mouse vas deferens: a pharmacological preparation sensitive to nociceptin

Eur J Pharmacol. 1996 Sep 5;311(1):R3-5. doi: 10.1016/0014-2999(96)00563-8.


The newly discovered neuropeptide, nociceptin (alias orphanin FQ), was tested for its potential direct effects, as well as for its ability to modify the electrically evoked contractions in several isolated organs suspended in vitro. The electrically stimulated mouse vas deferens is a sensitive preparation on which nociceptin exerts an inhibitory effect which is not affected by naloxone. The mouse vas deferens is therefore proposed as a bioassay for nociceptin and related compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Guinea Pigs
  • In Vitro Techniques
  • Male
  • Mice
  • Molecular Sequence Data
  • Muscle, Smooth / drug effects*
  • Opioid Peptides / pharmacology*
  • Receptors, Opioid / agonists*
  • Vas Deferens / drug effects*


  • Opioid Peptides
  • Receptors, Opioid
  • nociceptin