Beta-endorphin concentration in peripheral blood mononuclear cells of elderly depressed patients--effects of phosphatidylserine therapy

Neuropsychobiology. 1996;34(1):18-21. doi: 10.1159/000119285.


beta-Endorphin (beta-EP) concentrations were measured in peripheral blood mononuclear cells of 10 elderly women with major depressive disorders, 10 age- and sex-matched healthy controls and 10 young healthy controls. beta-EP values were measured in resting condition and after stimulation with corticotropin-releasing hormone (CRH). In patients, beta-EP values were measured in drug-free condition and after 30 days of treatment with phosphatidylserine (BCPS), 200 mg/day, p.o. Basal and CRH-stimulated beta-EP concentrations were the same in patients and controls; in patients they did not change after BCPS, in spite of significant improvement of the depressive symptomatology.

MeSH terms

  • Aged
  • Aging / metabolism*
  • Depressive Disorder / drug therapy*
  • Female
  • Humans
  • Monocytes / metabolism*
  • Phosphatidylserines / therapeutic use*
  • beta-Endorphin / metabolism*


  • Phosphatidylserines
  • beta-Endorphin