Alterations in pancreatic ductal morphology following polyethylene pancreatic stent therapy

Gastrointest Endosc. 1996 Sep;44(3):268-75. doi: 10.1016/s0016-5107(96)70163-3.


Background: Polyethylene stents placed in the main pancreatic duct induce morphologic alterations that may resemble chronic pancreatitis.

Methods: We reviewed the sequential pancreatograms of stented patients who had long-term follow-up after stent removal.

Results: Forty patients (66%) had a normal baseline pancreatogram, whereas 21 (34%) showed changes of chronic pancreatitis. In 49 of 61 patients (80.3%), one or more had new morphologic changes immediately after stent withdrawal graded as mild (69%), moderate (29%), or severe (2%). Changes included ductal irregularity (49%), narrowing (35.5%), and side branch change (15.5%). Sixteen of the 21 patients (76.1%) with an abnormal baseline pancreatogram had worsening of the baseline abnormality or additional changes while stented, whereas 33 of 40 (82.5%) with a normal baseline developed new morphologic changes. Correlation of stent-induced changes with stent size, length, patency at removal, and duration of stenting failed to show an association. Twenty-five patients with stent-induced changes had a follow-up pancreatogram at a mean of 192 days (10 to 740) after stent removal. There was complete resolution of the changes in 64%, partial resolution in 32%, and no improvement in 5%.

Conclusion: Morphologic changes induced by polyethylene pancreatic duct stents occurred in 80% of patients. More than one third of these changes did not resolve during the follow-up period. Because of concern over stent-induced fibrosis, the use of pancreatic stents should remain largely experimental.

MeSH terms

  • Follow-Up Studies
  • Humans
  • Pancreas / diagnostic imaging
  • Pancreatic Ducts / diagnostic imaging*
  • Pancreatitis / diagnostic imaging
  • Polyethylenes
  • Radiography
  • Stents / adverse effects*
  • Time Factors


  • Polyethylenes