Joint fluid carboxy-terminal type II procollagen peptide as a marker of cartilage collagen biosynthesis

Osteoarthritis Cartilage. 1993 Apr;1(2):121-8. doi: 10.1016/s1063-4584(05)80027-5.


Joint fluid levels of carboxy-terminal type II procollagen peptide (pCOL II-C) were measured in osteoarthritis, rheumatoid arthritis and traumatic arthritis by a newly developed one-step enzyme immunoassay (EIA). The detection limit of the new method was as low as 0.2 ng/ml. The levels of pCOL II-C were significantly (P < 0.001) higher in osteoarthritis and traumatic arthritis than in rheumatoid arthritis. In osteoarthritis, pCOL II-C levels were higher in moderately afflicted patients. Since type II collagen is a unique component of cartilage, pCOL II-C levels in joint fluids could reflect the synthetic activity of type II collagen of chondrocytes in the diseased joint and therefore could be utilized as a simple marker of type II collagen synthesis in articular cartilage in joint diseases.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Arthritis / etiology
  • Arthritis / metabolism
  • Arthritis, Rheumatoid / metabolism
  • Biomarkers
  • Cartilage, Articular / metabolism*
  • Collagen / biosynthesis*
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Knee Injuries / complications
  • Male
  • Middle Aged
  • Peptide Fragments / metabolism*
  • Procollagen / metabolism*
  • Reproducibility of Results
  • Synovial Fluid / metabolism*


  • Biomarkers
  • Peptide Fragments
  • Procollagen
  • procollagen type II carboxy-terminal peptide
  • Collagen