Abstract
Epidural hematoma is a rare cause of spinal cord compression, which usually provokes severe neurological deficits. It is presumed to originate from venous or, more probably, arterial bleeding. Thrombocytopenia and other disorders of coagulation may precipitate the onset of epidural hematoma and facilitate the evolution of the disease. We report the case of a patient suffering from a non-Hodgkin's lymphoma with severe thrombocytopenia during a MACOP-B schedule, who presented with a spontaneous cervical epidural hematoma. We discuss the etiopathological aspects, diagnosis, and treatment of this rare cause of acute cervical spinal cord compression.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bleomycin / adverse effects
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Bleomycin / therapeutic use
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Cyclophosphamide / adverse effects
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Cyclophosphamide / therapeutic use
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Doxorubicin / adverse effects
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Doxorubicin / therapeutic use
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Hematoma, Epidural, Cranial / diagnosis
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Hematoma, Epidural, Cranial / etiology*
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Hematoma, Epidural, Cranial / surgery
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Humans
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Leucovorin / adverse effects
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Leucovorin / therapeutic use
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Lymphoma, Non-Hodgkin / drug therapy*
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Male
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Methotrexate / adverse effects
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Methotrexate / therapeutic use
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Middle Aged
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Prednisone / adverse effects
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Prednisone / therapeutic use
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Spinal Cord Compression / diagnosis
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Spinal Cord Compression / etiology
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Spinal Cord Compression / surgery
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Thrombocytopenia / chemically induced
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Thrombocytopenia / complications*
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Vincristine / adverse effects
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Vincristine / therapeutic use
Substances
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Bleomycin
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Leucovorin
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Prednisone
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Methotrexate