A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy

Exp Clin Endocrinol Diabetes. 1996;104(4):311-6. doi: 10.1055/s-0029-1211460.

Abstract

In a double-blind, randomized, controlled study, the effectiveness of treatment with a combination of Benfotiamine (an Allithiamine, a lipid-soluble derivative of vitamin B1 with high bioavailability) plus vitamin B6/B12 on objective parameters of neuropathy was studied over a period of 12 weeks on 24 diabetic patients with diabetic polyneuropathy. The results showed a significant improvement (p = 0.006) of nerve conduction velocity in the peroneal nerve and a statistical trend toward improvement of the vibration perception threshold. Long-term observation of 9 patients with verum over a period of 9 months support the results. Therapy-specific adverse effects were not seen. The results of this double-blind investigation, of the long-term observation and of the reports in the literature support the contention that the neurotropic benfotiamine-vitamin B combination represents a starting point in the treatment of diabetic polyneuropathy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Aged
  • Capsules
  • Diabetic Neuropathies / drug therapy*
  • Diabetic Neuropathies / physiopathology
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Glycated Hemoglobin A / drug effects
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Male
  • Median Nerve / physiology
  • Middle Aged
  • Neural Conduction / drug effects
  • Neural Conduction / physiology
  • Perception / drug effects
  • Perception / physiology
  • Peroneal Nerve / physiology
  • Pyridoxine / administration & dosage
  • Pyridoxine / pharmacology
  • Pyridoxine / therapeutic use*
  • Sensory Thresholds / drug effects
  • Sensory Thresholds / physiology
  • Thiamine / administration & dosage
  • Thiamine / analogs & derivatives*
  • Thiamine / pharmacology
  • Thiamine / therapeutic use
  • Time Factors
  • Vibration
  • Vitamin B 12 / administration & dosage
  • Vitamin B 12 / pharmacology
  • Vitamin B 12 / therapeutic use*

Substances

  • Capsules
  • Drug Combinations
  • Glycated Hemoglobin A
  • Pyridoxine
  • Vitamin B 12
  • Thiamine
  • benphothiamine